Chemical and Biological weapons remain a subversive threat to civilizational stability. Biological weapons in particular are a tremendous cause for concern given the difficulty in predicting/preparing for an attack and the complexities of post-attack rehabilitation. Furthermore, the problems of attrition and lack of culpability make it an even more tempting form of warfare for Non State Actors and Extremists. It is important therefore, to examine the current climate of extremism and the potential threat posed by the usage of Chemical and Biological weapons. Having gained access to Iraqi chemical weapon stockpiles, the Islamic State has already engaged in Chemical warfare. This paper attempts to conjecture the possibility of their move towards Biological warfare and the aids/deterrents that could facilitate or block such a transition.